Mary travels from Honduras to the United States border in search of her son, a migrant kidnapped in Mexico. During her journey, she meets other mothers who are looking for their children and understands the magnitude of the disappearance crisis in the region. Francisco, a leader of the Pesh ethnic group, confronts the destruction of the tropical rainforest, the migration of his children, and the disappearance of his language.

"Toshkua," a word that means "to disappear" in the Pesh language of Honduras, tells the story of those who fight against disappearance, from Central America to the United States.